PittsburghV1, France, Analysis, bibRecord, 000556

NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

Identifieur interne : 000556 ( France/Analysis ); précédent : 000555; suivant : 000557

NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

Auteurs : Roger Stupp [Suisse] ; Erict. Wong [États-Unis] ; Andrewa. Kanner [Israël] ; David Steinberg [Israël] ; Herbert Engelhard [États-Unis] ; Volkmar Heidecke [Allemagne] ; Eilon D. Kirson [Israël] ; Sophie Taillibert [France] ; Frank Liebermann [États-Unis] ; Vladimir Dbaly [République tchèque] ; Zvi Ram [Israël] ; J. Lee Villano [États-Unis] ; Nikolai Rainov [Allemagne] ; Uri Weinberg [Israël] ; David Schiff [États-Unis] ; Lara Kunschner [États-Unis] ; Jeffrey Raizer [États-Unis] ; Jerome Honnorat [France] ; Andrew Sloan [États-Unis] ; Mark Malkin [États-Unis] ; Joseph C. Landolfi [États-Unis] ; Franz Payer [Autriche] ; Maximilian Mehdorn [Allemagne] ; Robert J. Weil [États-Unis] ; Susan C. Pannullo [États-Unis] ; Manfred Westphal [Allemagne] ; Martin Smrcka [République tchèque] ; Lawrence Chin [États-Unis] ; Herwig Kostron [Autriche] ; Silvia Hofer ; Jeffrey Bruce ; Rees Cosgrove ; Nina Paleologous ; Yoram Palti [Israël] ; Philip H. Gutin

Source :

European journal of cancer : (1990) [ 0959-8049 ] ; 2012.

RBID : Pascal:12-0372762

Descripteurs français

Pascal (Inist)
- Chimiothérapie, Etude comparative, Médecin, Glioblastome, Choix, Essai clinique phase III, Récidive, Essai clinique, Tumeur intracrânienne, Cancérologie.
Wicri :
- topic : Médecin.

English descriptors

KwdEn :
- Cancerology, Chemotherapy, Choice, Clinical trial, Comparative study, Glioblastoma, Intracranial tumor, Phase III trial, Physician, Relapse.

Abstract

Purpose: NovoTTF-100A is a portable device delivering low-intensity, intermediate frequency electric fields via non-invasive, transducer arrays. Tumour Treatment Fields (TTF), a completely new therapeutic modality in cancer treatment, physically interfere with cell division. Methods: Phase III trial of chemotherapy-free treatment of NovoTTF (20-24 h/day) versus active chemotherapy in the treatment of patients with recurrent glioblastoma. Primary endpoint was improvement of overall survival. Results: Patients (median age 54 years (range 23-80), Karnofsky performance status 80% (range 50-100) were randomised to TTF alone (n = 120) or active chemotherapy control (n = 117). Number of prior treatments was two (range 1-6). Median survival was 6.6 versus 6.0 months (hazard ratio 0.86 [95% CI 0.66-1.12]; p = 0.27), 1-year survival rate was 20% and 20%, progression-free survival rate at 6 months was 21.4% and 15.1% (p = 0.13), respectively in TTF and active control patients. Responses were more common in the TTF arm (14% versus 9.6%, p = 0.19). The TTF-related adverse events were mild (14%) to moderate (2%) skin rash beneath the transducer arrays. Severe adverse events occurred in 6% and 16% (p = 0.022) of patients treated with TTF and chemotherapy, respectively. Quality of life analyses favoured TTF therapy in most domains. Conclusions: This is the first controlled trial evaluating an entirely novel cancer treatment modality delivering electric fields rather than chemotherapy. No improvement in overall survival was demonstrated, however efficacy and activity with this chemotherapy-free treatment device appears comparable to chemotherapy regimens that are commonly used for recurrent glioblastoma. Toxicity and quality of life clearly favoured TTF.

Affiliations:

Allemagne, Autriche, France, Israël, République tchèque, Suisse, États-Unis
Auvergne-Rhône-Alpes, Bavière, Bohême centrale, Canton de Vaud, District de Souabe, Hambourg, Illinois, Moravie, Rhône-Alpes, Schleswig-Holstein, Île-de-France
Augsbourg, Brno, Chicago, Hambourg, Kiel, Lausanne, Lyon, Paris, Prague
Université de l'Illinois à Chicago

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 003829
to stream PascalFrancis, to step Curation: 001692
to stream PascalFrancis, to step Checkpoint: 002E30
to stream Main, to step Merge: 009116
to stream Main, to step Curation: 008B22
to stream Main, to step Exploration: 008B22
to stream France, to step Extraction: 000556

Links to Exploration step

Pascal:12-0372762

Le document en format XML

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<author><name sortKey="Gutin, Philip H" sort="Gutin, Philip H" uniqKey="Gutin P" first="Philip H." last="Gutin">Philip H. Gutin</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality</title>
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</affiliation>
</author>
<author><name sortKey="Wong, Erict" sort="Wong, Erict" uniqKey="Wong E" first="Erict." last="Wong">Erict. Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Harvard Medical School, Beth Israel Deaconess Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanner, Andrewa" sort="Kanner, Andrewa" uniqKey="Kanner A" first="Andrewa." last="Kanner">Andrewa. Kanner</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Tel Aviv Medical Center</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Tel Aviv Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Steinberg, David" sort="Steinberg, David" uniqKey="Steinberg D" first="David" last="Steinberg">David Steinberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Tel Aviv University</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Engelhard, Herbert" sort="Engelhard, Herbert" uniqKey="Engelhard H" first="Herbert" last="Engelhard">Herbert Engelhard</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>University of Illinois at Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Heidecke, Volkmar" sort="Heidecke, Volkmar" uniqKey="Heidecke V" first="Volkmar" last="Heidecke">Volkmar Heidecke</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Augsburg Clinic</s1>
<s2>Augsburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirson, Eilon D" sort="Kirson, Eilon D" uniqKey="Kirson E" first="Eilon D." last="Kirson">Eilon D. Kirson</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Novocure Ltd.</s1>
<s2>Haifa</s2>
<s3>ISR</s3>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Novocure Ltd.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taillibert, Sophie" sort="Taillibert, Sophie" uniqKey="Taillibert S" first="Sophie" last="Taillibert">Sophie Taillibert</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hospital de la Pitie-Salpetriere</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liebermann, Frank" sort="Liebermann, Frank" uniqKey="Liebermann F" first="Frank" last="Liebermann">Frank Liebermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University of Pittsburgh Medical Center</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Pittsburgh Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dbaly, Vladimir" sort="Dbaly, Vladimir" uniqKey="Dbaly V" first="Vladimir" last="Dbaly">Vladimir Dbaly</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Na Homolce Hospital</s1>
<s2>Prague</s2>
<s3>CZE</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>République tchèque</country>
<placeName><settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ram, Zvi" sort="Ram, Zvi" uniqKey="Ram Z" first="Zvi" last="Ram">Zvi Ram</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Tel Aviv Medical Center</s1>
<s2>Tel Aviv</s2>
<s3>ISR</s3>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Tel Aviv Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Villano, J Lee" sort="Villano, J Lee" uniqKey="Villano J" first="J. Lee" last="Villano">J. Lee Villano</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>University of Illinois at Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Rainov, Nikolai" sort="Rainov, Nikolai" uniqKey="Rainov N" first="Nikolai" last="Rainov">Nikolai Rainov</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Augsburg Clinic</s1>
<s2>Augsburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weinberg, Uri" sort="Weinberg, Uri" uniqKey="Weinberg U" first="Uri" last="Weinberg">Uri Weinberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Novocure Ltd.</s1>
<s2>Haifa</s2>
<s3>ISR</s3>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Novocure Ltd.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schiff, David" sort="Schiff, David" uniqKey="Schiff D" first="David" last="Schiff">David Schiff</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University of Virginia</s1>
<s2>Charlottesville, VA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Virginia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kunschner, Lara" sort="Kunschner, Lara" uniqKey="Kunschner L" first="Lara" last="Kunschner">Lara Kunschner</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Allegheny Neurological Brain Tumor Center</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Allegheny Neurological Brain Tumor Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Raizer, Jeffrey" sort="Raizer, Jeffrey" uniqKey="Raizer J" first="Jeffrey" last="Raizer">Jeffrey Raizer</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Northwestern University</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Northwestern University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Honnorat, Jerome" sort="Honnorat, Jerome" uniqKey="Honnorat J" first="Jerome" last="Honnorat">Jerome Honnorat</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Neuro-Oncology, Hospices Civils de Lyon, Université Claude Bernard</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Andrew" sort="Sloan, Andrew" uniqKey="Sloan A" first="Andrew" last="Sloan">Andrew Sloan</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>University Hospitals of Cleueland, Case Western Reserve University School of Medicine</s1>
<s2>Cleveland, OH</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cleveland, OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malkin, Mark" sort="Malkin, Mark" uniqKey="Malkin M" first="Mark" last="Malkin">Mark Malkin</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Medical College of Wisconsin</s1>
<s2>Milwaukee, WI</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Medical College of Wisconsin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landolfi, Joseph C" sort="Landolfi, Joseph C" uniqKey="Landolfi J" first="Joseph C." last="Landolfi">Joseph C. Landolfi</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>New Jersey Neuroscience Institute at JFK Medical Center</s1>
<s2>Edison, NY</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New Jersey Neuroscience Institute at JFK Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Payer, Franz" sort="Payer, Franz" uniqKey="Payer F" first="Franz" last="Payer">Franz Payer</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University Graz</s1>
<s2>Graz</s2>
<s3>AUT</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehdorn, Maximilian" sort="Mehdorn, Maximilian" uniqKey="Mehdorn M" first="Maximilian" last="Mehdorn">Maximilian Mehdorn</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>University of Kiel</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weil, Robert J" sort="Weil, Robert J" uniqKey="Weil R" first="Robert J." last="Weil">Robert J. Weil</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>The Cleveland Clinic Foundation-Taussig Cancer Center</s1>
<s2>Cleveland, OH</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The Cleveland Clinic Foundation-Taussig Cancer Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pannullo, Susan C" sort="Pannullo, Susan C" uniqKey="Pannullo S" first="Susan C." last="Pannullo">Susan C. Pannullo</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>New York Presbyterian Hospital-Weill Cornell Medical Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New York Presbyterian Hospital-Weill Cornell Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Westphal, Manfred" sort="Westphal, Manfred" uniqKey="Westphal M" first="Manfred" last="Westphal">Manfred Westphal</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>University of Hamburg</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smrcka, Martin" sort="Smrcka, Martin" uniqKey="Smrcka M" first="Martin" last="Smrcka">Martin Smrcka</name>
<affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Brno University Hospital</s1>
<s2>Brno</s2>
<s3>CZE</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>République tchèque</country>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chin, Lawrence" sort="Chin, Lawrence" uniqKey="Chin L" first="Lawrence" last="Chin">Lawrence Chin</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Boston Medical Center</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kostron, Herwig" sort="Kostron, Herwig" uniqKey="Kostron H" first="Herwig" last="Kostron">Herwig Kostron</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>University of Innsbruck</s1>
<s3>AUT</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
</author>
<author><name sortKey="Bruce, Jeffrey" sort="Bruce, Jeffrey" uniqKey="Bruce J" first="Jeffrey" last="Bruce">Jeffrey Bruce</name>
</author>
<author><name sortKey="Cosgrove, Rees" sort="Cosgrove, Rees" uniqKey="Cosgrove R" first="Rees" last="Cosgrove">Rees Cosgrove</name>
</author>
<author><name sortKey="Paleologous, Nina" sort="Paleologous, Nina" uniqKey="Paleologous N" first="Nina" last="Paleologous">Nina Paleologous</name>
</author>
<author><name sortKey="Palti, Yoram" sort="Palti, Yoram" uniqKey="Palti Y" first="Yoram" last="Palti">Yoram Palti</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Novocure Ltd.</s1>
<s2>Haifa</s2>
<s3>ISR</s3>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Novocure Ltd.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gutin, Philip H" sort="Gutin, Philip H" uniqKey="Gutin P" first="Philip H." last="Gutin">Philip H. Gutin</name>
</author>
</analytic>
<series><title level="j" type="main">European journal of cancer : (1990)</title>
<title level="j" type="abbreviated">Eur. j. cancer : (1990)</title>
<idno type="ISSN">0959-8049</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">European journal of cancer : (1990)</title>
<title level="j" type="abbreviated">Eur. j. cancer : (1990)</title>
<idno type="ISSN">0959-8049</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Chemotherapy</term>
<term>Choice</term>
<term>Clinical trial</term>
<term>Comparative study</term>
<term>Glioblastoma</term>
<term>Intracranial tumor</term>
<term>Phase III trial</term>
<term>Physician</term>
<term>Relapse</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term>
<term>Etude comparative</term>
<term>Médecin</term>
<term>Glioblastome</term>
<term>Choix</term>
<term>Essai clinique phase III</term>
<term>Récidive</term>
<term>Essai clinique</term>
<term>Tumeur intracrânienne</term>
<term>Cancérologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose: NovoTTF-100A is a portable device delivering low-intensity, intermediate frequency electric fields via non-invasive, transducer arrays. Tumour Treatment Fields (TTF), a completely new therapeutic modality in cancer treatment, physically interfere with cell division. Methods: Phase III trial of chemotherapy-free treatment of NovoTTF (20-24 h/day) versus active chemotherapy in the treatment of patients with recurrent glioblastoma. Primary endpoint was improvement of overall survival. Results: Patients (median age 54 years (range 23-80), Karnofsky performance status 80% (range 50-100) were randomised to TTF alone (n = 120) or active chemotherapy control (n = 117). Number of prior treatments was two (range 1-6). Median survival was 6.6 versus 6.0 months (hazard ratio 0.86 [95% CI 0.66-1.12]; p = 0.27), 1-year survival rate was 20% and 20%, progression-free survival rate at 6 months was 21.4% and 15.1% (p = 0.13), respectively in TTF and active control patients. Responses were more common in the TTF arm (14% versus 9.6%, p = 0.19). The TTF-related adverse events were mild (14%) to moderate (2%) skin rash beneath the transducer arrays. Severe adverse events occurred in 6% and 16% (p = 0.022) of patients treated with TTF and chemotherapy, respectively. Quality of life analyses favoured TTF therapy in most domains. Conclusions: This is the first controlled trial evaluating an entirely novel cancer treatment modality delivering electric fields rather than chemotherapy. No improvement in overall survival was demonstrated, however efficacy and activity with this chemotherapy-free treatment device appears comparable to chemotherapy regimens that are commonly used for recurrent glioblastoma. Toxicity and quality of life clearly favoured TTF.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>France</li>
<li>Israël</li>
<li>République tchèque</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Bavière</li>
<li>Bohême centrale</li>
<li>Canton de Vaud</li>
<li>District de Souabe</li>
<li>Hambourg</li>
<li>Illinois</li>
<li>Moravie</li>
<li>Rhône-Alpes</li>
<li>Schleswig-Holstein</li>
<li>Île-de-France</li>
</region>
<settlement><li>Augsbourg</li>
<li>Brno</li>
<li>Chicago</li>
<li>Hambourg</li>
<li>Kiel</li>
<li>Lausanne</li>
<li>Lyon</li>
<li>Paris</li>
<li>Prague</li>
</settlement>
<orgName><li>Université de l'Illinois à Chicago</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Bruce, Jeffrey" sort="Bruce, Jeffrey" uniqKey="Bruce J" first="Jeffrey" last="Bruce">Jeffrey Bruce</name>
<name sortKey="Cosgrove, Rees" sort="Cosgrove, Rees" uniqKey="Cosgrove R" first="Rees" last="Cosgrove">Rees Cosgrove</name>
<name sortKey="Gutin, Philip H" sort="Gutin, Philip H" uniqKey="Gutin P" first="Philip H." last="Gutin">Philip H. Gutin</name>
<name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
<name sortKey="Paleologous, Nina" sort="Paleologous, Nina" uniqKey="Paleologous N" first="Nina" last="Paleologous">Nina Paleologous</name>
</noCountry>
<country name="Suisse"><region name="Canton de Vaud"><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Wong, Erict" sort="Wong, Erict" uniqKey="Wong E" first="Erict." last="Wong">Erict. Wong</name>
</noRegion>
<name sortKey="Chin, Lawrence" sort="Chin, Lawrence" uniqKey="Chin L" first="Lawrence" last="Chin">Lawrence Chin</name>
<name sortKey="Engelhard, Herbert" sort="Engelhard, Herbert" uniqKey="Engelhard H" first="Herbert" last="Engelhard">Herbert Engelhard</name>
<name sortKey="Kunschner, Lara" sort="Kunschner, Lara" uniqKey="Kunschner L" first="Lara" last="Kunschner">Lara Kunschner</name>
<name sortKey="Landolfi, Joseph C" sort="Landolfi, Joseph C" uniqKey="Landolfi J" first="Joseph C." last="Landolfi">Joseph C. Landolfi</name>
<name sortKey="Liebermann, Frank" sort="Liebermann, Frank" uniqKey="Liebermann F" first="Frank" last="Liebermann">Frank Liebermann</name>
<name sortKey="Malkin, Mark" sort="Malkin, Mark" uniqKey="Malkin M" first="Mark" last="Malkin">Mark Malkin</name>
<name sortKey="Pannullo, Susan C" sort="Pannullo, Susan C" uniqKey="Pannullo S" first="Susan C." last="Pannullo">Susan C. Pannullo</name>
<name sortKey="Raizer, Jeffrey" sort="Raizer, Jeffrey" uniqKey="Raizer J" first="Jeffrey" last="Raizer">Jeffrey Raizer</name>
<name sortKey="Schiff, David" sort="Schiff, David" uniqKey="Schiff D" first="David" last="Schiff">David Schiff</name>
<name sortKey="Sloan, Andrew" sort="Sloan, Andrew" uniqKey="Sloan A" first="Andrew" last="Sloan">Andrew Sloan</name>
<name sortKey="Villano, J Lee" sort="Villano, J Lee" uniqKey="Villano J" first="J. Lee" last="Villano">J. Lee Villano</name>
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<country name="Allemagne"><region name="Bavière"><name sortKey="Heidecke, Volkmar" sort="Heidecke, Volkmar" uniqKey="Heidecke V" first="Volkmar" last="Heidecke">Volkmar Heidecke</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Taillibert, Sophie" sort="Taillibert, Sophie" uniqKey="Taillibert S" first="Sophie" last="Taillibert">Sophie Taillibert</name>
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<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Dbaly, Vladimir" sort="Dbaly, Vladimir" uniqKey="Dbaly V" first="Vladimir" last="Dbaly">Vladimir Dbaly</name>
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   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
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   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:12-0372762
   |texte=   NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality
}}

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NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

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